U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 3

            INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

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1.   Name and Address of Reporting Person*

                             ORBIMED ADVISORS, LLC
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   (Last)                            (First)              (Middle)

                          767 Third Avenue, 6th Floor
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                                    (Street)

New York                                NY                  10010
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   (City)                            (State)                (Zip)

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2.   Date of Event Requiring Statement (Month/Day/Year)

                                 July 30, 1999
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3.   IRS Identification Number of Reporting Person, if an Entity (Voluntary)


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4.   Issuer Name and Ticker or Trading Symbol

                      DISCOVERY LABORATORIES, INC. (DSCO)
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5.   Relationship of Reporting Person to Issuer
     (Check all applicable)

     [_]  Director                             [X]  10% Owner
     [_]  Officer (give title below)           [_]  Other (specify below)


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6.   If Amendment, Date of Original (Month/Day/Year)


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7.   Individual or Joint/Group Filing  (Check applicable line)

     [_]  Form Filed by One Reporting Person

     [_]  Form Filed by More than One Reporting Person

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             Table I -- Non-Derivative Securities Beneficially Owned
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                                                                 3. Ownership Form:
                                      2. Amount of Securities       Direct (D) or
1. Title of Security                     Beneficially Owned         Indirect (I)       4. Nature of Indirect Beneficial Ownership
   (Instr. 4)                            (Instr. 4)                 (Instr. 5)            (Instr. 4)
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Common Stock                             661,157                     I                    By Caduceus Capital Trust
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Common Stock                             200,000                     I                    By Caduceus Capital II, L.P.
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Common Stock                             826,446                     I                    By Finsbury Worldwide Pharmaceutical Trust
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*    If the Form is filed by more than one  Reporting  Person,  see  Instruction
     5(b)(v).

Reminder: Report on a separate line for each class of securities beneficially
          owned directly or indirectly.


                                                                          (Over)
(Form 3-07/99)

FORM 3 (continued) Table II -- Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) ================================================================================ 5. Owner- 3. Title and Amount of Securities ship Underlying Derivative Security Form of 2. Date Exercisable (Instr. 4) Derivative and Expiration Date --------------------------------- 4. Conver- Security: (Month/Day/Year) Amount sion or Direct 6. Nature of ---------------------- or Exercise (D) or Indirect Date Expira- Number Price of Indirect Beneficial 1. Title of Derivative Exer- tion of Derivative (I) Ownership Security (Instr. 4) cisable Date Title Shares Security (Instr. 5) (Instr. 5) - ------------------------------------------------------------------------------------------------------------------------------------ Common Stock Warrants July 28, July 27, Common Stock 661,157 I By Caduceus (Right to Buy) 1999 2004 Capital Trust - ------------------------------------------------------------------------------------------------------------------------------------ Common Stock Warrants July 28, July 27, Common Stock 165,289 I By Caduceus (Right to Buy) 1999 2004 Capital II, L.P. - ------------------------------------------------------------------------------------------------------------------------------------ Common Stock Warrants July 28, July 27, Common Stock 826,446 I By Finsbury (Right to Buy) 1999 2004 Worldwide Pharmaceutical Trust - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ - ------------------------------------------------------------------------------------------------------------------------------------ ==================================================================================================================================== Explanation of Responses: /s/Samuel D. Isaly Managing Member of OrbiMed Advisors, LLC February 23, 2000 - --------------------------------------------- ----------------------- **Signature of Reporting Person Date ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure. Page 2

Signature Page for Other Reporting Persons: CADUCEUS CAPITAL TRUST By: /s/Deborah O'Donnel ---------------------- Name: Deborah O'Donnel Title: Secretary CADUCEUS CAPITAL II, L.P. By: OrbiMed Advisors LLC, its general partner By: /s/Samuel D. Isaly ---------------------- Name: Samuel D. Isaly Title: Managing Member FINSBURY WORLDWIDE PHARMACEUTICAL TRUST By: /s/Samuel D. Isaly ---------------------- Name: Samuel D. Isaly Title: Director Page 3

Designated Filer - ---------------- OrbiMed Advisors, LLC Date of Event Requiring Statement--7/30/99 Issuer Name - DISCOVERY LABORATORIES, INC. Trading Symbol-"DSCO" Other Reporting Persons: ------------------------ Caduceus Capital Trust c/o OrbiMed Advisors, LLC 767 Third Avenue, 6th Floor New York, NY 10010 Caduceus Capital II, L.P. c/o OrbiMed Advisors, LLC 767 Third Avenue, 6th Floor New York, NY 10010 Finsbury Worldwide Pharmaceutical, Trust c/o OrbiMed Advisors, LLC 767 Third Avenue, 6th Floor New York, NY 10010 Page 4