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PROSPECTUS
SUPPLEMENT NO. 8
(TO
PROSPECTUS DATED JUNE 18, 2008)
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Filed
pursuant to Rule 424(b)(3)
under
the Securities Act of 1933 in connection with
Registration
Statement No. 333-151536
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Common
Stock
This
Prospectus Supplement No. 8 supplements and amends the prospectus dated June 18,
2008 relating to the resale of up to 20,153,000 shares of our common stock by
Kingsbridge Capital Limited (“Kingsbridge”).
This
prospectus supplement should be read in conjunction with the prospectus dated
June 18, 2008, Prospectus Supplement No. 1 dated July 11, 2008, Prospectus
Supplement No. 2 dated August 1, 2008, Prospectus Supplement No. 3 dated October
20, 2008, Prospectus Supplement No. 4 dated November 21, 2008, Prospectus
Supplement No. 5 dated December 31, 2008, Prospectus Supplement No. 6 dated
January 21, 2009, and Prospectus Supplement No. 7 dated February 18, 2009, which
are to be delivered with this prospectus supplement. This prospectus supplement
is not complete without, and may not be delivered or utilized except in
connection with, the prospectus, including any supplements or amendments to
it. All references in the prospectus to “this prospectus” are hereby
amended to read “this prospectus (as supplemented and amended).”
We are
filing this prospectus supplement to reflect a draw down by us pursuant to the
Common Stock Purchase Agreement, dated May 22, 2008, between Kingsbridge and
ourselves.
The table
appearing under the caption “Selling Stockholder” on page 24 of the prospectus
is hereby further supplemented and amended by adding the following to the end of
footnote (2) to that table, as previously supplemented and amended:
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“On
March 18, 2009, we delivered a notice to Kingsbridge to effect a draw down
of up to $1,250,000. The first trading day of the eight-day
pricing period for this draw down was March 19, 2009. In
connection with this draw down, we issued an aggregate of 1,015,127 shares
of our common stock to Kingsbridge at an aggregate purchase price of
$1,093,750. The settlement dates for this draw down were March
25, 2009 and March 31, 2009.”
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Investing
in our common stock involves significant risks. See “Risk Factors”
beginning on Page 7 of the prospectus, as well as the section entitled “Risk
Factors” included in our recent quarterly and annual reports filed with the
Securities and Exchange Commission.
Neither
the Securities and Exchange Commission nor any state securities commission has
approved or disapproved of these securities or determined if this prospectus is
truthful or complete. Any representation to the contrary is a criminal
offense.
The date
of this prospectus supplement is March 31, 2009.