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PROSPECTUS
SUPPLEMENT NO. 5
(TO
PROSPECTUS DATED JUNE 18, 2008)
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Filed
pursuant to Rule 424(b)(3)
under
the Securities Act of 1933 in connection with
Registration
Statement No. 333-151536
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Common
Stock
This
Prospectus Supplement No. 5 supplements and amends the prospectus dated June 18,
2008 relating to the resale of up to 20,153,000 shares of our common stock by
Kingsbridge Capital Limited (“Kingsbridge”).
This
prospectus supplement should be read in conjunction with the prospectus dated
June 18, 2008, Prospectus Supplement No. 1 dated July 11, 2008, Prospectus
Supplement No. 2 dated August 1, 2008, Prospectus Supplement No. 3 dated October
20, 2008, and Prospectus Supplement No. 4 dated November 21, 2008, which are to
be delivered with this prospectus supplement. This prospectus supplement is not
complete without, and may not be delivered or utilized except in connection
with, the prospectus, including any supplements or amendments to
it. All references in the prospectus to “this prospectus” are hereby
amended to read “this prospectus (as supplemented and amended).”
We are
filing this prospectus supplement to reflect a draw down by us pursuant to the
Common Stock Purchase Agreement, dated May 22, 2008, between Kingsbridge and
ourselves.
The table
appearing under the caption “Selling Stockholder” on page 24 of the prospectus
is hereby further supplemented and amended by adding the following to the end of
footnote (2) to that table, as previously supplemented and amended:
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“On
December 17, 2008, we delivered a notice to Kingsbridge to effect a draw
down of up to $1,000,000. The first trading day of the
eight-day pricing period for this draw down was December 18,
2008. In connection with this draw down, we issued an aggregate
of 478,783 shares of our common stock to Kingsbridge at an aggregate
purchase price of $500,000, with scheduled settlement dates of December
23, 2008 and December 31, 2008.”
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Investing
in our common stock involves significant risks. See “Risk Factors”
beginning on Page 7 of the prospectus, as well as the section entitled “Risk
Factors” included in our recent quarterly and annual reports filed with the
Securities and Exchange Commission.
Neither
the Securities and Exchange Commission nor any state securities commission has
approved or disapproved of these securities or determined if this prospectus is
truthful or complete. Any representation to the contrary is a criminal
offense.
The date
of this prospectus supplement is December 31, 2008.