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PROSPECTUS
SUPPLEMENT NO. 4
(TO
PROSPECTUS DATED JUNE 18, 2008)
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Filed
pursuant to Rule 424(b)(3)
under
the Securities Act of 1933 in connection with
Registration
Statement No. 333-151536
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Common
Stock
This
Prospectus Supplement No. 4 supplements and amends the prospectus dated
June 18, 2008 relating to the resale of up to 20,153,000 shares of our common
stock by Kingsbridge Capital Limited (“Kingsbridge”).
This
prospectus supplement should be read in conjunction with the prospectus dated
June 18, 2008, Prospectus Supplement No. 1 dated July 11, 2008, Prospectus
Supplement No. 2 dated August 1, 2008 and Prospectus Supplement No. 3 dated
October 20, 2008, which are to be delivered with this prospectus supplement.
This prospectus supplement is not complete without, and may not be delivered
or
utilized except in connection with, the prospectus, including any supplements
or
amendments to it. All references in the prospectus to “this prospectus” are
hereby amended to read “this prospectus (as supplemented and
amended).”
We
are
filing this prospectus supplement to reflect a draw down by us pursuant to
the
Common Stock Purchase Agreement, dated May 22, 2008, between Kingsbridge and
ourselves.
The
table
appearing under the caption “Selling Stockholder” on page 24 of the prospectus
is hereby further supplemented and amended by adding the following to the end
of
footnote (2) to that table, as previously supplemented and amended:
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·
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“On
November 10, 2008, we delivered a notice to Kingsbridge to effect
a draw
down of up to $2,000,000. The first trading day of the eight day
pricing
period for this draw down was November 11, 2008. In connection with
this
draw down, we issued an aggregate of 221,202 shares of our common
stock to
Kingsbridge at an aggregate purchase price of $250,000. The settlement
date for this drawdown was November 17, 2008.”
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Investing
in our common stock involves significant risks. See “Risk Factors” beginning on
Page 7 of the prospectus, as well as the section entitled “Risk Factors”
included in our recent quarterly and annual reports filed with the Securities
and Exchange Commission.
Neither
the Securities and Exchange Commission nor any state securities commission
has
approved or disapproved of these securities or determined if this prospectus
is
truthful or complete. Any representation to the contrary is a criminal offense.
The
date
of this prospectus supplement is November 21,
2008.