Filed pursuant to Rule 424(b)(3)
relating to Registration Statement No. 333-107836

DISCOVERY LABORATORIES, INC.
SUPPLEMENT DATED APRIL 7, 2006
TO PROSPECTUS DATED AUGUST 8, 2003

This Supplement should be read in conjunction with the Preliminary Prospectus, dated August 8, 2003, contained in Registration Statement No. 333-107836 (the “Registration Statement”) of Discovery Laboratories, Inc., as amended and supplemented by (i) the Pre-Effective Amendment No. 1 to the Registration Statement filed with the Securities and Exchange Commission (the “Commission”) on August 21, 2003, including the Preliminary Prospectus, dated August 20, 2003, contained therein, and including the exhibits thereto, (ii) the Prospectus Supplement, dated April 16, 2004, filed with the Commission on April 16, 2004, (iii) the Prospectus Supplement, dated May 9, 2005, filed with the Commission on May 9, 2005, (iv) the Prospectus Supplement, dated February 17, 2006, filed with the Commission on February 17, 2006 and (v) the Prospectus Supplement, dated March 21, 2006, filed with the Commission on March 21, 2006.

Sargon Capital International Fund Ltd. has assigned its Class A Investor Warrant to purchase 18,579 shares of our common stock to SDS Capital Group SPC, Ltd. Accordingly, the Selling Stockholder table contained in the Prospectus, as amended and supplemented, is further amended, as set forth below, by (i) deleting the entry for Sargon Capital International Fund Ltd. and (ii) adding an entry for SDS Capital Group SPC, Ltd.
 
Our common stock, par value $.001 per share, is listed on the Nasdaq National Market under the symbol “DSCO”. On April 6, 2006, the closing sale price for the common stock, as reported on the Nasdaq National Market, was $4.63.

Neither the Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.
 
 
 

 

The information appearing in the following table supplements or supersedes in part the information in the table under the heading “Selling Stockholders” in the Preliminary Prospectus, dated August 20, 2003, as amended and supplemented.

SELLING STOCKHOLDERS

Name
Number of
Shares of
common stock,
 not including
Warrants,
Beneficially
Owned
Number of
Shares
represented
by Warrants
Beneficially
Owned
Total
Number of
Shares of
common
stock
Beneficially
Owned +
Percentage
Beneficially
Owned
Before
Offering
Number of
Shares to be
Offered for
the Account
of Selling
Stockholders
Number of
Shares to
be Owned
after this
Offering
Percentage
to be
Beneficially
Owned After
this Offering

SDS Capital
Group SPC, Ltd.
0
18,579
18,579
18,579
0
*
------------------------
* Less than 1%.

+ The information contained in this table reflects “beneficial” ownership of common stock within the meaning of Rule 13d-3 under the Securities Exchange Act of 1934. Beneficial ownership information reflected in the table includes shares of common stock issuable upon the exercise of outstanding warrants.


Please keep this supplement with your Prospectus.
 
 
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