Filed pursuant to Rule 424(b)(3)
relating to Registration Statement No. 333-107836


DISCOVERY LABORATORIES, INC.
SUPPLEMENT DATED FEBRUARY 17, 2006
TO PROSPECTUS DATED AUGUST 8, 2003

This Supplement should be read in conjunction with the Preliminary Prospectus, dated August 8, 2003, contained in Registration Statement No. 333-107836 (the “Registration Statement”) of Discovery Laboratories, Inc., as amended and supplemented by (i) the Pre-Effective Amendment No. 1 to the Registration Statement filed with the Securities and Exchange Commission (the “Commission”) on August 21, 2003, including the Preliminary Prospectus, dated August 20, 2003, contained therein, and including the exhibits thereto, (ii) the Prospectus Supplement, dated April 16, 2004, filed with the Commission on April 16, 2004, and (iii) the Prospectus Supplement, dated May 9, 2005, filed with the Commission on May 9, 2005.

The Selling Stockholder table contained in such Prospectus, as amended and supplemented, is further amended, as set forth below, by (i) deleting the entry for QFinance, Inc. (“QFinance”) in the Selling Stockholders table and (ii) replacing the entry for PharmaBio Development Inc. (“PharmaBio”) with the updated and additional information in the Selling Stockholders table set forth in this Supplement. QFinance merged with and into PharmaBio on December 31, 2005.
 
Our common stock, par value $.001 per share, is listed on the Nasdaq National Market under the symbol “DSCO”. On February 16, 2006, the closing sale price for the common stock, as reported on the Nasdaq National Market, was $7.97.

Neither the SEC nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.

The information appearing in the following table supplements or supersedes in part the information in the table under the heading “Selling Stockholders” in the Preliminary Prospectus dated August 20, 2003, as amended and supplemented.

SELLING STOCKHOLDERS
 
Name
Number of Shares of common stock, not including Warrants, Beneficially Owned
 
Number of Shares represented by Warrants Beneficially Owned
 
Total Number of Shares of common stock Beneficially Owned +
Percentage Beneficially Owned Before Offering
 
Number of Shares to be Offered for the Account of Selling Stockholders
 
Number of Shares to be Owned after this Offering
 
Percentage to be Beneficially Owned After this Offering
                         
PharmaBio Development Inc.
1,276,210
 
840,566
 
2,116,776
5.43%
 
1,730,719
 
386,057
 
*
 
____________
* Less than 1%.

+ The information contained in this table reflects “beneficial” ownership of common stock within the meaning of Rule 13d-3 under the Securities Exchange Act of 1934. Beneficial ownership information reflected in the table includes shares of common stock issuable upon the exercise of outstanding warrants.

Please keep this supplement with your Prospectus.