- ---------------
    FORM 5
- ---------------

[ ] Check this box if no longer subject of Section 16. 

    Form 4 or Form 5 obligations may continue. See Instruction 1(b).

[X] Form 3 Holdings Reported

[ ] Form 4 Transactions Reported

                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

               ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

- --------------------------------------------------------------------------------
1. Name and Address of Reporting Person

The Aries Fund, a Cayman Island Trust
- --------------------------------------------------------------------------------
   (Last)               (First)                 (Middle)

c/o MeesPierson (Cayman) Limited,
P.O. Box 2003, British American  
Centre, Phase 3, Dr. Roy's Drive 
- --------------------------------------------------------------------------------
                                    (Street)

George Town, Grand Cayman
- --------------------------------------------------------------------------------
   (City)               (State)                 (Zip)


- --------------------------------------------------------------------------------
2. Issuer Name and Ticker or Trading Symbol

Discovery Laboratories, Inc. 

DSCO                         
- --------------------------------------------------------------------------------
3. IRS or Social Security Number of Reporting Person (Voluntary)


- --------------------------------------------------------------------------------
4. Statement for Month/Year

December 1997
- --------------------------------------------------------------------------------
5. If Amendment, Date of Original (Month/Year)


- --------------------------------------------------------------------------------
6. Relationship of Reporting Person to Issuer
   (Check all applicable)

[ ]   Director                             [X]   10% Owner
[ ]   Officer (give title below)           [ ]   Other (specify below)


____________________________________________________________________

- --------------------------------------------------------------------------------
           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
- --------------------------------------------------------------------------------


                                                                                             5.             6.           
                                                           4.                                Amount of      Owner-       
                                                           Security Acquired (A) or          Securities     ship          
                                                           Disposed of (D)                   Beneficially   Form:         7.        
                                                           (Instr. 3, 4 and 5)               Owned at End   Direct        Nature of 
                        2.                3.               -----------------------------     of Issuer's    (D) or        Indirect  
1.                      Transaction       Transaction          Amount      (A)    Price      Fiscal Year    Indirect      Beneficial
Title of Security       Date              Code                             or                (Instr. 3      (I)           Ownership 
(Instr. 3)              (Month/Day/Year)  (Instr. 8)                       (D)               & 4)           (Instr.4)     (Instr. 4)
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                  
Common Stock            11/25/97           J(1)(2)             337,107     A      (1)        337,107        D
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly.

                            (Print or type Responses)

FORM 5 (continued) Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) - ------------------------------------------------------------------------------------------------------------------------------------ 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. Title of Conver- Trans- Trans- Number of Date Title and Amount Price Number Owner- Nature Derivative sion action action Derivative Exercisable and of Underlying of of ship of Security or Date Code Securities Expiration Date Securities Deriv- Deriv- of In- (Instr. 3) Exer- (Month/ (Instr. Acquired (A) (Month/Day/Year) (Instr. 3 and 4) ative ative Deriv- direct cise Day/ 8) or Disposed ---------------- ---------------- Secur- Secur- ative Bene- Price Year) of (D) Date Expira- Title Amount ity ities Secur- ficial of (Instr. 3, Exer- tion or (Instr. Bene- ity: Owner- Deriv- 4 and 5) cisable Date Number 5) ficially Direct ship ative ------------ of Owned (D) or (Instr. Secur- (A) (D) Shares at End In- 4) ity of direct Year (I) (Instr. (Instr. 4) 4) - ------------------------------------------------------------------------------------------------------------------------------------ Series B Convertible Common Preferred Stock $6.42 11/25/97 J(1)(3) 173,250 11/25/97 N/A Stock 269,686 (1) 173,250 D - ------------------------------------------------------------------------------------------------------------------------------------ Common Stock Common Warrants $0.64 11/15/96 J(4) 6,129 5/15/97 11/15/06 Stock 6,129 (1) 6,129 D - ------------------------------------------------------------------------------------------------------------------------------------ Series B Series B Convert- Convertible ible Preferred Stock Preferred Warrants $11.00 11/15/96 J(4) 15,750 5/15/97 11/15/06 Stock 15,750 (1) 15,750 D - ------------------------------------------------------------------------------------------------------------------------------------ Explanation of Responses: (1) Securities acquired pursuant to the statutory merger (the "Merger") of Discovery Laboratories, Inc., a former Delaware corporation ("Old Discovery") with and into the Issuer (f/k/a Ansan Pharmaceuticals, Inc.). Pursuant to the Merger, securities of Old Discovery held by the Reporting Person were converted into securities of the Issuer. The securities of Old Discovery surrendered by the Reporting Person in the Merger constituted the consideration for the securities of the Issuer issued to the Reporting Person in the Merger. The securities of Old Discovery were not listed on a securities exchange or quoted on an inter-dealer quotation system and, accordingly, the Issuer is unable to determine the value of such consideration as of the date of the Merger. (2) Includes 269,686 shares of Common Stock issuable upon conversion of Series B Convertible Preferred Stock (including Series B Convertible Preferred Stock issuable upon exercise of Series B Convertible Preferred Stock Warrants) and 6,129 shares of Common Stock issuable upon exercise of Common Stock Warrants. (3) Includes 15,750 shares of Series B Convertible Preferred Stock issuable upon exercise of Series B Convertible Preferred Stock Warrants. (4) The Common Stock Warrants and Series B Convertible Preferred Stock Warrants were issued to the Reporting Person in connection with a private placement of equity securities of Old Discovery in which an affiliate of the Reporting Person acted as placement agent. The Common Stock Warrants and Series B Convertible Preferred Stock Warrants were assumed by the Issuer in the Merger. /s/ Lindsay A. Rosenwald February 13, 1998 - --------------------------------------------- ----------------------- **Signature of Reporting Person Date ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure. Page 2