Filed pursuant to Rule 424(b)(3)
                                          relating to Registration No. 333-86105

                          DISCOVERY LABORATORIES, INC.
                         SUPPLEMENT DATED JUNE 21, 2001
                      TO PROSPECTUS DATED NOVEMBER 4, 1999

            This Supplement should be read in conjunction with the Prospectus
dated November 4, 1999, contained in Registration Statement No. 333-86105 of
Discovery Laboratories, Inc., as amended and supplemented and including the
exhibits thereto. The selling stockholder table contained in such Prospectus is
amended by deleting the references to The Aries Domestic Fund, L.P., and The
Aries Master Fund (collectively, the "Aries Funds"), and adding the entities
listed in the table below as new selling stockholders (the "Selling
Stockholders"). The Aries Funds have transferred all of the securities
registered for resale pursuant to the above-referenced Registration Statement
and Prospectus to the Selling Stockholders. Each of the Aries Funds and the
Selling Stockholders may be deemed to be an affiliate of the Company.

            Our common stock, par value $.001 per share (the "Common Stock"), is
listed on the Nasdaq SmallCap Market under the symbol "DSCO". On June 20, 2001,
the closing sale price for the Common Stock, as reported on the Nasdaq Small Cap
Market, was $3.82. We advise you to obtain a current market quotation for the
Common Stock.

            Neither the SEC nor any state securities commission has approved or
disapproved of these securities or determined if this prospectus supplement is
truthful or complete. Any representation to the contrary is a criminal offense.

SELLING STOCKHOLDERS

            The Selling Stockholders may offer and sell a total of 767,511
shares of Common Stock under the Prospectus. The shares being offered under the
Prospectus were acquired by the Selling Stockholders upon the transfer of
securities we issued to the Aries Funds in connection with a private placement
completed by us in July 1999 (the "Private Placement"). In connection with the
Private Placement, we agreed to register these shares for the Aries Funds and
their assignees under the Securities Act of 1933.

            The following table sets forth, to the best of our knowledge, based
on information provided to us by the Selling Stockholders:

o     the number of shares of the Common Stock owned by each Selling
      Stockholder; and

o     the number of shares being offered by each Selling Stockholder under the
      Prospectus.

            All information with respect to share ownership has been provided by
the Selling Stockholders as of a recent date. Because the Selling Stockholders
identified below may have sold, transferred or otherwise disposed of all or a
portion of the shares of Common Stock owned


by them since the date on which they provided us with the information regarding their share ownership in transactions exempt from the registration requirements of the Securities Act of 1933, no estimate can be given as to the number of shares of Common Stock that will be held by the Selling Stockholders after the offering. The information appearing in the following table supplements or supersedes in part the information in the table under the heading "Selling Stockholders" in the Prospectus and was provided by or on behalf of the entities named below, as of May 18, 2001. Number of Shares of Number of common stock, Shares Total Number of Number of Shares not including represented by Shares of Percentage to be Offered for Warrants, Warrants Common Stock Beneficially the Account of Beneficially Beneficially Beneficially Owned Before Selling Name Owned Owned Owned + Offering Stockholders - ---------------------------- ----------------- ----------------- ----------------- ----------------- ------------------ Aries Select I LLC 440,800 23,641 464,441 2.2% 230,253 Aries Select Ltd. 1,068,541 55,164 1,123,705 5.3% 537,258 Number of Percentage to Shares to be be Beneficially Owned after Owned After Name this Offering this Offering - ----------------------------- -------------- ----------------- Aries Select I LLC 234,188 1.1% Aries Select Ltd. 586,447 2.8% - ------------------------ + The information contained in this table reflects "beneficial" ownership of Common Stock within the meaning of Rule 13d-3 under the Exchange Act. On May 18, 2001, we had 21,173,383 shares of Common Stock outstanding. Beneficial ownership information reflected in the table includes shares of Common Stock issuable upon the exercise of outstanding warrants issued by us. 2