FORM 5 [ ] Check this box if no longer subject to Section 16, Form 4 or Form 5 obligations may continue. See Instruction 1(b) [ ] Form 3 Holdings Reported [ X ] Form 4 Transactions Reported U. S. SECURITIES AND EXCHANGE COMMISSION Washington, D. C. 20549 ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940 - -------------------------------------------------------------------------------- 1. Name and address of Reporting Person McDade, Herbert H. Jr. - -------------------------------------------------------------------------------- (Last) (First) (MI) 660 White Plains Road, Suite 400 - -------------------------------------------------------------------------------- (Street) Tarrytown NY 10501 - -------------------------------------------------------------------------------- (City) (State) (Zip) - -------------------------------------------------------------------------------- 2. Issuer Name and Ticker or Trading Symbol Discovery Laboratories, Inc. ("Discovery") DSCO - -------------------------------------------------------------------------------- 3. IRS or Social Security Number of Reporting Person (Voluntary) 000-00-0000 - -------------------------------------------------------------------------------- 4. Statement for Month/Year | 5. If Amendment, Date of | Original (Month/Year) | June 1998 | - -------------------------------------------------------------------------------- 6. Relationship of Reporting to Issuer (Check all applicable) [ X ] Director [ ] 10% Owner [ ] Officer [ ] Other (specify below) (give title below) - --------------------------------------------------------------------------------

- ------------------------------------------------------------------------------- TABLE I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned - ------------------------------------------------------------------------------- - ----------------------------------------------------------------------------------------------------------------------------------- 1. Title of Security | 2. Transaction Date | 3. Transaction Code | 4. Securities Acquired (A) or Disposed (Instr. 3) | (Month/Day/Year) | (Instr. 8) | of (D) (Instr. 3, 4 & 5) | | | - ------------------------------------------------------------------------------------------------------------------------------------ | | | Amount | (A)or | Price | | | | (D) | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | =================================================================================================================================== - ----------------------------------------------------------------------------------------------------------------------------------- 1. Title of Security | 5. Amount of Securities | 6. Ownership Form: | 7. Nature of Indirect Beneficial (Instr. 3) | Beneficially Owned at | Direct (D) or | Ownership (Instr. 4) | End of Fiscal Year | Indirect (I) | | (Instr. 3 & 4) | (Instr. 4) | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | =================================================================================================================================== Reminder: Report on a separte line for each class of securities beneficially owned directly or indirectly. (Print or type Reponses)

Form 5 - ------------------------------------------------------------------------------- TABLE II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) - ------------------------------------------------------------------------------- - ----------------------------------------------------------------------------------------------------------------------------------- 1. Title of Derivative Security | 2. Conversion or | 3. Transaction Date | 4. Transaction | 5. Number of Derivative (Instr. 3) | Exercise Price of | (Month/Day/Year) | Code | Securities Acquired | Derivative Security | | (Instr. 8) | (A) or Disposed of | | | | (D) (Instr. 3, 4 & 5) - ----------------------------------------------------------------------------------------------------------------------------------- | | | | (A) | (D) - ----------------------------------------------------------------------------------------------------------------------------------- Non-Statutory Stock Option(1) | $2.66 | 6/16/98 | A,4 | 10,000 | | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | =================================================================================================================================== - ----------------------------------------------------------------------------------------------------------------------------------- 1. Title of Derivative Security | 6. Date Exercisable and | 7. Title and Amount of Underlying | 8. Price of Derivative (Instr. 3) | Expiration Date | Securities (Instr. 3 & 4) | Security (Instr. 5) | (Month/Day/Year) | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | Date | Expiration | Title | Amount or Number | | Exercisable | Date | | of Shares | | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | 6/16/98(2) | 6/16/08 | Common | 10,000 | | | | Stock | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | | | ===================================================================================================================================

- ----------------------------------------------------------------------------------------------------------------------------------- 1. Title of Derivative Security | 9. Number of Derivative | 10. Ownership Form of Derivative | 11. Nature of Indirect (Instr. 3) | Securities Beneficially | Security: Direct (D) or | Beneficial Ownership | Owned at End of Year | Indirect (I) (Instr. 4) | (Instr. 4) | (Instr. 4) | | - ----------------------------------------------------------------------------------------------------------------------------------- | 23,619 | D | | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | - ----------------------------------------------------------------------------------------------------------------------------------- | | | =================================================================================================================================== Explanation of Responses: (1) Represents a right to buy. (2) Unvested shares of Common Stock of the Issuer subject to such options will be subject to repurchase by the Company, at the then exercise price per share, upon the Reporting Persons cessation of Board service. The shares of Common Stock of the Issuer subject to such options will vest (and the Company's repurchase rights will lapse) in four successive equal annual installments over the Reporting Person's period of service, beginning six months after the option grant date. ** Intentional Misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). /s/ Herbert McDade March 31, 1999 - ------------------------------------ ------------------- **Signature of Reporting Person Date Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure. page 2